Dopamine and Anxiety

Dopamine is also involved in regulating anxiety. An imbalance in dopamine levels can contribute to the development of anxiety disorders. New research seeks to understand this complex relationship and identify new therapeutic strategies.

Recent research highlights the complex role of dopamine in anxiety and depression. Dopamine modulates anxiety through interactions with the amygdala, prefrontal cortex, and other brain regions (Zarrindast & Khakpai, 2015; Mora et al., 2010). Both D1 and D2 dopamine receptors are involved, with D1 activation generally producing anxiogenic effects and D2 activation having context-dependent effects (Mora et al., 2010). Dopamine imbalances are implicated in various mental disorders, including anxiety and depression (Kostic & Rodrigues, 2023). The relationship between dopamine and these disorders is intricate, involving interactions with other neurotransmitters like serotonin, noradrenaline, GABA, and glutamate (Kostic & Rodrigues, 2023). Understanding these mechanisms is crucial for developing effective treatments for anxiety and depression (Pavei et al., 2023). Research in this area aims to elucidate the physiological mechanisms underlying these disorders and their relationship with dopamine, potentially leading to improved therapeutic strategies (Pavei et al., 2023).

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10.1016/j.pneurobio.2009.10.010

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